Biomedical Sciences Department |
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| Frank
Sylvester, Ph.D. Assistant Professor Biomedical Science Department 221 Padnos Allendale, MI 49401 Phone: 331-8707 Fax: 331-2090 email: sylvestf@gvsu.edu |
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| FALL OFFICE HOURS: Dr. Sylvester is on Sabbatical for Fall 2008. |
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| COURSES TAUGHT BMS 208 - Human Anatomy BMS 290 - Human Physiology BMS 291 - Human Physiology Laboratory BMS 309 - Human Anatomy Lab BMS 375 - The Biology of Aging |
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| EDUCATION/TRAINING 1993 BS Cornell University in Animal Science 1997 MA Drake University in Biology 2002 PhD Medical College of Wisconsin in physiology 2002 postdoctoral fellow at the Medical College of Wisconsin |
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| RESEARCH INTERESTS My laboratory studies alterations in the function of blood vessels in response to various male hormones known as androgens. I am particularly interested in determining androgen-induced changes in blood flow regulation in different caliber arteries, since the regulation of blood flow is often heterogeneous. This area of research utilizes multiple experimental techniques including in vitro and in situ tissue preparations, protein expression and function assays, and whole animal instrumentation. Androgens are an example of a group of hormones known as steroids. Steroids have been shown to significantly alter the function of blood vessels and may constitute an appropriate means for combating and/or treating vascular disease. It is hoped that insight gained from these studies may lead to an improved understanding of cardiovascular diseases such as hypertension (i.e. high blood pressure). |
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| PUBLICATIONS 1. F.A. Sylvester, J.C. Frisbee, and J.H. Lombard. Longitudinal differences in vascular control mechanisms in isolated resistance arteries of the rat cremaster muscle. Microvasc. Res. 60:160-167, 2000. 2. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. Contribution of extrinsic factors and intrinsic vascular alterations to reduced arteriolar reactivity with high salt diet and hypertension. Microcirculation. 7:281-289, 2000. 3. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries. Am. J. Physiol. 281:H1808-H1815, 2001. 4. F.A. Sylvester, D.W. Stepp, J.C. Frisbee, and J.H. Lombard. High-salt diet depresses acetylcholine reactivity proximal to NOS activation in cerebral arteries. Am. J. Physiol. 283:H353-H363, 2002. 5. J.H. Lombard, F.A. Sylvester, S.A. Phillips, and J.C. Frisbee. High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. Am. J. Physiol. 284:H1124-H1133, 2003. 6. S.A. Phillips, F.A. Sylvester, and J.C. Frisbee. Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats. Am. J. Physiol. 288:R522-530, 2005. |
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| Biomedical Sciences Department |  |
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| Last updated September 03, 2008 | Copyright (c) 1998 GVSU | |