Research in the Hecht Lab
The focus of our laboratory is student involvement in virological research at Grand Valley State University. We have several areas of current research and I have some outside collaborations. In each case, we try to involve undergraduates interested in working hard and getting a taste of research.
Current research areas:
Endogenous Retroviruses of Sheep and Goats
Sheep and goats are closely related ruminants and, like all of us, have many retroviruses that have integrated into their genomes and are now part of their genetic make-up. We have been examining the integration sites of these endogenous retroviruses, looking for those that are shared between goats and sheep and those that are not shared as clues into the function, role, and potential contribution of these viruses to the shaping of their host species.
Anti-virals: Screening for potential chemotherapuetic
compounds that could be used to treat viral infections
In conjunction with Dr. Miles Hacker, several undergraduates have been developing assays for anti-viral agents. The advent of antibiotics made a tremendous difference in our ability to treat bacterial infections. In the future, being able to actually treat viral diseases would have a tremendous impact on our world. A large bank of potential compounds to test is available from Dr. Hacker's research.
One system involves using a yeast-based element to test for anti-AIDS drugs to the reverse transcriptase. Another system involves using a bacteriophage with the HIV protease. Both of these are systems that are safe for undergraduate labs to use and experience this type of research, and were supplied by researchers at the NCI.
Molecular Ecology of Host and Viral Species
Rodent reservoirs of zoonotics: Noninvasive fingerprinting
In conjunction with Joe Jacquot, mammologist in the department of biology at GVSU, we are developing RAPD fingerprint techniques for rodents sampled in the local region. We hope to correlate populations and vector capacity.
Interaction of immune system, parasites, and mate choice in wild turkeys
In conjunction with Richard Buchholz at the University of Mississippi & Ann Findley at the University of Louisiana-Monroe, we have been investigating the interplay of turkey MHC loci, mate choice, and parasite load. Dr. Buchholz heads this work and for more information, please see the link above and see the "mate choice" links.
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Last updated August 10, 2001 |
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